Pancreatic stone protein levels accurately predict severity in sepsis of various causes earlier than other biomarkers. Author: Kouroupis
Abstract
Objective: To evaluate the prognostic value of Pancreatic Stone Protein (PSP) in sepsis compared to conventional biomarkers (WBC, CRP, PCT).
Methods: Conducted in an emergency department setting, the study included 28 patients with sepsis of diverse origins (respiratory, urinary, bloodstream infections, etc.). PSP levels were measured using the abioSCOPE® with an IVD CAPSULE PSP, leveraging nanofluidic technology to deliver results in 5 minutes.
Results: PSP levels were significantly higher in Gram-negative sepsis and bacteremia, correlating with worse outcomes (p=0.006). Unlike WBC, CRP, and PCT, PSP predicted severity and mortality earlier, upon admission, while other biomarkers only showed prognostic significance 48 hours later. PSP also associated with acute kidney injury (*p* = 0.027) and was elevated in bloodstream infections (mean 378 ng/ml).
Conclusion: PSP emerges as a promising early biomarker for sepsis severity, offering speed and specificity advantages over traditional markers
Full article: https://doi.org/10.1016/j.mimet.2025.107129